WHO Technical Report Series Series 971

Research Priorities for Zoonoses and Marginalized Infections

Technical Report of the TDR Disease Reference Group on Zoonoses and Marginalized Infectious Diseases of Poverty

Paperback
February 2013
9789241209717
More details
  • Publisher
    World Health Organization
  • Published
    27th February 2013
  • ISBN 9789241209717
  • Language English
  • Pages 130 pp.
  • Size 8.25" x 11.75"
$48.00

This report provides a review and analysis of the research landscape for zoonoses and marginalized infections which affect poor populations, and a list of research priorities to support disease control. The work is the output of the disease reference group on zoonoses and marginalized infectious diseases (DRG6), which is part of an independent think tank of international experts, established and funded by the Special Programme for Research and Training in Tropical Diseases (TDR), to identify key research priorities through the review of research evidence and input from stakeholder consultations.

The report covers a diverse range of diseases including zoonotic helminth protozoa, viral and bacterial infections considered to be neglected and associated with poverty. Disease-specific research issues were elaborated under individual disease sections and many common priorities were readily identified among the disease such as need for new and/or improved drugs and regimens, diagnostics and, where appropriate, vaccines. The disease specific priorities are described as micro priorities compared with the macro level priorities which will drive such policies as the need for improved surveillance; the need for inter-sectoral interaction between health, livestock, agriculture, natural resources and wildlife in tackling the zoonotic diseases; and the need for a true assessment of the burden of the zoonoses.

This is one of ten disease and thematic reference group reports that have come out of the TDR Think Tank, all of which have contributed to the development of the Global Report for Research on Infectious Diseases of Poverty.

EXECUTIVE SUMMARY

1. INTRODUCTION

1.1 Rationale and context
1.1 Zoonoses and the Millenium Development Goals
1.2 Challenges
1.3 Scope of the report
1.4 Group membership
1.5 Host country
1.6 Think tank members

2. METHODOLOGY AND PRIORITIZATION
2.1 Informal consultation
2.2 Selection of DRG members
2.3 First DRG meeting
2.4 Stakeholder consultations
2.5 Second DRG meeting
2.6 Priorization Process
2.7 Transformation of DRG report to TRS

3. BURDEN OF DISEASE
3.1Estimating the burden of parasitic zoonoses: approaches and challenges
3.1.1 Measures of mortality, morbidity and health-associated life years (HALYs)
3.1.2 Economic (monetary) burden of zoonotic disease
3.1.3 Case studies
3.2 Disease-specific issues and burden
3.2.1 Helminths
3.2.2 Protozoan infections
3.2.3 Bacterial infections
3.2.4 Viral infections

4. INTERVENTION-ORIENTED RESEARCH ISSUES
4.1 Community-led or community-directed interventions
4.1.1 Community-led Total Sanitation (CLTS)
4.1.2 CLTS and zoonotic diseases
4.2 The human/animal interface: "One Health" as a concept
4.3 Chemotherapy and immunization
4.3.1 Mass chemotherapy (mass-targeted, humans-animals)
4.3.2 Immunization against rabies
4.4 Vector and intermediate host control
4.5 Vaccination as a control option for zoonotic diseases
4.5.1 Animal-targeted immunization
4.5.2 Echinococcus granulosus
4.5.3 Vaccine against Taenia solium
4.5.4 Foodborne trematode vaccines
4.6 Human-targeted vaccines
4.6.1 Enteric infections
4.7 Animal reservoirs
4.8 Health education and health literacy
4.9 Development of human resources
4.10 Integrated approaches
4.11 New products and strategies
4.12 Health systems and interactions with other sectors: intersectoral dialogue
4.13 Cost?effectiveness analysis

5. DISEASE-SPECIFIC AND INTERVENTION-SPECIFIC PRIORITIES FOR RESEARCH
5.1 Disease-specific research priorities
5.1.1 Cysticercosis and taeniasis
5.1.2 Echinococcosis
5.1.3 Asian schistosomiasis
5.1.4 Foodborne trematodiases
5.1.5 Toxoplasmosis
5.1.6 Cryptosporidiosis
5.1.8 Bacterial zoonoses
5.1.9 Enteric infections
5.2 Intervention-specific research priorities
5.2.1 Community-led Total Sanitation
5.2.2 Animal/human interface
5.2.3 Epidemiological studies
5.2.4 Health education and promotion

6. CROSS-GROUP ISSUES AND PRIORITIES
6.1 Interactions with Disease and Thematic Reference Groups
6.2 Priorities for policy-makers

7. CONCLUSIONS

8. ACKOWLEDGEMENTS

9. REFERENCES

10. APPENDICES

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